After Tetsuo Shima's rampage through Neo-Tokyo, and discovery of Akira's dissection, Colonel Shikishima orders the use of SOL to kill Tetsuo. The first shot fired from SOL destroyed Tetsuo's right arm, and interrupts his fight with Shotaro Kaneda. The SOL is destroyed by Tetsuo soon after.
When Tetsuo free's Akira from containment, and is leading him over the ridge of the crater, SOL is used against him, under The Colonel's orders. SOL destroy's Tetsuo's right arm in this attack. After Akira destroys Neo-Tokyo; SOL is re-purposed to target a point specified using a handheld laser. It is used in an attempt on Tetsuo's life during the Great Tokyo Empire's siege of Lady Miyako's temple.